Tuesday, November 25, 2008

Grapefruit Warning

Maybe all you Lipitor-takers are aware of this, but this was news to me.

Patients taking many common medications should be weary of consuming grapefruit. Grapefruit (and grapefruit juice and grapefruit supplements) interact with these medications preventing (as I understand it) a liver enzyme from metabolizing the medication and thereby creating unsafe levels of the drug in the body.

Medications that may be affected include
  • Anxiety: Xanax, Buspar, Versed, Halcion
  • Depression: Luvox, Zoloft
  • Allergies: Allegra
  • Abnormal heart rhythm: Cordarone, quinidine
  • Heart disease/stroke/blood clots: Coumadin
  • Epilepsy: Tegretol
  • Cancer: Cyclophosphamide, etoposide, ifosfamide, tamoxifen, vinblastine, vincristine
  • Cough: Dextromethorphan (found in many over-the-counter cold medicines)
  • HIV: Agenerase, Crixivan, Viracept, Norvir, Fortovase
  • Prostate enlargement: Proscar
  • Heart disease/High blood pressure: Coreg, Cardizem, Plendil, Cardene, Adalat, Procardia,
  • Nimotop, Sular, Covera, Calan, Verelan
  • Erectile dysfunction: Viagra, Cialis
  • Asthma/Emphysema: Theophylline
  • High cholesterol: Lipitor, Lescol, Mevacor, Zocor
  • Pain: Alfenta, Duragesic, Actiq, Sufenta
  • Infection: Biaxin, Sporanox, erythromycin, troleandomycin
Often, a patient can be switched to another drug in the same class that will not interact. (For instance, Pravachol is less likely to interact with grapefruit.) There is some evidence that adjusting the time you eat grapefruit and the time you take your meds may be effective. (This is inconsistently supported in the research.)

As always, ask your doctor and/or pharmacist. Make sure he's aware of all supplements, etc., you are taking. Make sure YOU understand any warnings, precautions, etc., that may accompany your medications.

For more information check out the following links (provided by my dietician cousin!)

3 comments:

Anonymous said...

Great informational Post Rachel. I do, however, know all about this subject because I am an RN. I'm looking forward to our next support group meeting, December 4th right?

Anonymous said...

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Wheelie said...

I'll do a little more research - but my GP warned me about pineapple too, but as with grapefruit, it may well depend on the medication one is on and even the result of the interaction between meds.

Bit of a minefield isn't it?